Osama bin Laden, the leader of al-Qaeda, is dead.
US president Barack Obama said bin Laden, the most-wanted fugitive on the US list, has been killed on Sunday in a US operation in the Pakistani city of Abbottabad, about 150km north of Islamabad.
"Tonight, I can report to the people of the United States and the world, the United States had carried an operation that has killed Osama Bin Laden, a terrorist responsible for killing thousands of innocent people," Obama said in a statement.
"Today, at my direction, the United States carried out that operation... they killed Osama Bin Laden and took custody of his body.
"The death of Bin Laden marks the most significant achievement to date against Al Qaeda.
"We must also reaffirm that United states is not and will never be at war against Islam. Bin Laden was not a Muslim leader, in fact, he slaughtered many Muslims," Obama said.
Qais Azimy, Al Jazeera's correspondent in Kabul, said that Afghan officials have confirmed that bin Laden had died and that his body was with the United States.
The officials said the death of the al-Qaeda leader was more of a "symbolic victory", as he was no longer directly connected to the group's field operations, Azimy reported.
It is a major accomplishment for Obama and his national security team. Obama's predecessor, George Bush, had repeatedly vowed to bring to justice the mastermind of the September 11, 2001, attacks on New York and Washington, but never did before leaving office in early 2009.
He had been the subject of a search since he eluded US soldiers and Afghan militia forces in a large-scale assault on the Tora Bora mountains in 2001. The trail quickly went cold after he disappeared and many intelligence officials believed he had been hiding in Pakistan.
While in hiding, bin Laden had taunted the West and advocated his views in videotapes spirited from his hideaway.
Besides September 11, Washington has also linked bin Laden to a string of attacks -- including the 1998 bombings of American embassies in Kenya and Tanzania and the 2000 bombing of the warship USS Cole in Yemen.
Having the body may help convince any doubters that bin Laden is really dead.